Business marketplace BizBuySell's latest quarterly Insight Report on nationwide sales trends shows a 48% jump in the number of businesses listed on its network that sold during the first half of 2008, compared to the year-earlier period. A total of 3,894 businesses found buyers, up from 2,640 in the first half of 2007.

"When the economy slows, business executives want to downsize and employees have a fear of being transferred, outsourced or fired," he said. "As a result, these employees see small-business ownership as an attractive and viable opportunity." Plus, layoffs often bring with them severance packages - a good source of capital for people considering launching their own ventures.

At the high end of the market, sales are shakier. Two years ago, a feeding frenzy of small business sales was driven in part by the easy availability of credit and financing for acquisitions. Today, banks are warier about lending.

Private equity network NVST, which gathers information on merger and acquisition market activity, is having a hard time finding completed transactions. "I attribute this to the downturn of economy and lack of available credit for financing deals," said NVST editor Andrew Dolbeck.

Indeed, according to FactSet Mergerstat the number of deals valued at $100 million or less started plummeting in 2007. In the first two quarters of 2008, FactSet tracked 3,106 companies sold, down from 4,433 companies in the same quarters last year.

But while Wall Street struggles, buyers and sellers sticking to Main Street are still seeing a robust market.

"It's a good time to buy if you have the resources," Handelsman said. "And because valuations are on the rise, it's an even a better time to sell."